Endocrine Abstracts

Case: A GP with autoimmune hypothyroidism presented with a phaeochromocytoma during labour at the age of 36 y. A left adrenalectomy confirmed the diagnosis and a basal cell carcinoma was also removed. She had a history of Dupuytren's lesions of both soles and palms starting in her teenage years and multiple keratosis. There was no family history of any endocrine or skin disorder. At 41y, a benign breast lump was removed and also a gastrointestinal spindle cell stromal tumour (...

Case: A GP with autoimmune hypothyroidism presented with a phaeochromocytoma during labour at the age of 36 y. A left adrenalectomy confirmed the diagnosis and a basal cell carcinoma was also removed. She had a history of Dupuytren's lesions of both soles and palms starting in her teenage years and multiple keratosis. There was no family history of any endocrine or skin disorder. At 41y, a benign breast lump was removed and also a gastrointestinal spindle cell stromal tumour (...

PCOS is a chronic medical condition consisting of PCO on ultrasound in conjunction with menstrual cycle disturbance, insulin resistance, obesity and/or hyperandrogenism manifest as acne, hirsutism and androgenic alopecia. These symptoms can be expected to have a significant impact on quality of life. The aim of this study was to compare the health-related quality of life (HRQoL) of women with PCOS with that of women in the general population.HRQoL is generally measured by ...

Isolated hyperreninemic hypoaldosteronism presents in infancy with failure to thrive, hyponatremia, hyperkalemia, markedly elevated plasma renin activity, and low or inappropriately normal aldosterone. It is usually caused by mutations in the CYP11B2 gene encoding aldosterone synthase. Patients have normal cortisol levels and no features of congenital adrenal hyperplasia. We report a patient who presented with hyperreninemic hypoaldosteronism in early infancy.<p class="abs...

Hashimoto’s thyroiditis (HT) is the most common inflammatory condition of the thyroid gland. In addition to the classic variant of HT, several other subtypes have been identified, such as the fibrous variant (HTFV).Case history: A 38 years old man noticed a rapidly enlarging lump in his neck month ago. This resulted in discomfort with choking sensation and mild dysphagia. He mentioned weight loss, tiredness and night sweats. He was a smoker and dran...

vHL disease is commonly inherited in an autosomal dominant fashion. Pancreatic lesions in vHL are generally asymptomatic or associated with mild nonspecific symptoms.Case history: A 40 year old Asian female was seen in genetic/endocrine clinic for Predictive vHL mutation. She was married to her first cousin and had a 19 years old daughter. Her sister was diagnosed with vHL in Canada. She presented with Renal cell carcinoma and renal cysts. Her mother die...

Hashimoto’s thyroiditis (HT) is the most common inflammatory condition of the thyroid gland. In addition to the classic variant of HT, several other subtypes have been identified, such as the fibrous variant (HTFV).Case history: A 38 years old man noticed a rapidly enlarging lump in his neck month ago. This resulted in discomfort with choking sensation and mild dysphagia. He mentioned weight loss, tiredness and night sweats. He was a smoker and dran...

Delay in diagnosis of adrenal insufficiency is common. About 47% of patients have symptoms for over 1 year and 20% for over 5 years before diagnosis. Autoimmunity is the most common aetiology for Primary Adrenal Insufficiency (PAI) in developed countries. But up to 10–20% of PAI could be due to TB.We present an interesting case of 42 year old Afro Caribbean male with isolated adrenal TB. He had 2 year history of nonspecific illness including reduced...

Aims and objectives: Patients with thyroid dysfunction typically require frequent monitoring of thyroid function tests in order to titrate drug treatments and achieve normal thyroid function. A nurse-led thyroid telephone consulting service was established in 2006 to allow monitoring of thyroid function tests without the need for a hospital doctor’s appointment, with the aim of offering increased convenience for patients as well as significant cost savings. This audit aim...

A 63 year old lady born in Ghana was referred by her general practitioner for assessment of secondary hyperparathyroidism. She had corrected calcium of 1.93 (N: 2.18–2.47 mmol/L), PTH72.2 (N: 1.1–6.9 pmol/L) and alkaline phosphates of 324 (30–100 IU/L). Her GP described her to be very conscious about her weight and she virtually lived on fruits and vegetables. She has history of hyper tension and was on alpha-blocker. Examination revealed BMI of 29 Kg/m2</s...